Dr. Charles Marmar, the Lucius N. Littauer Professor

Project Overview

The Brockman Foundation has provided funding for the first clinical trial to test the efficacy of Cannabidiol (CBD) for reducing symptoms and neurocognitive impairment associated with post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). This will be the largest and most sophisticated study of the neurological effects of CBDs to date, and as such it holds the potential for generating an effective treatment of PTSD.

CBD is a safe, non-addictive compound found in cannabis. Its broad range of therapeutic actions have been demonstrated in preclinical studies and have spurred clinical investigations across a variety of neurological and psychiatric disorders. CBD is particularly promising for PTSD and TBI given its anxiolytic, neuroprotective and pro-cognitive actions, but it has not yet been evaluated in clinical trials for these indications.

Research is being led by Dr. Charles Marmar, who is internationally renowned for his expertise in PTSD. Given the critical importance of informing clinical trial outcomes with personalized medicine, Dr. Marmar and his research team will acquire comprehensive neuroimaging and blood-based circuit and molecular biomarkers before and after treatment with CBD.

They will use this information in machine learning based analyses centered on neural processes underlying fear extinction and emotion regulation to identify patient characteristics associated with treatment response, and to understand CBD’s mechanisms of action.

Dr. Charles Marmar is the Lucius N. Littauer Professor and Chair of the Department of Psychiatry, New York University Langone Health (NYULH), and the Director of the Center for Alcohol Use disorder and PTSD. He previously was Professor & Vice Chair of the Department of Psychiatry at University of California San Francisco & Associate Chief of Staff for Mental Health & Director of the PTSD Research Program at the San Francisco VA Medical Center.

His focus ranges from combat-related conditions in Veterans, including Iraq and Afghanistan Veterans, to PTSD in refugees and earthquake victims. An award-winning teacher and researcher, Dr. Marmar is currently the principal investigator of numerous PTSD-related grants funded by the Department of Defense and private philanthropic organizations.

Project Highlights

  • Overview: Efficacy of Cannabidiol